hCGbeta core fragment is a metabolite of hCG: evidence from infusion of recombinant hCG
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چکیده
منابع مشابه
Interaction of human chorionic gonadotropin (hCG) and asialo-hCG with recombinant human thyrotropin receptor.
hCG is a putative thyroid stimulator. The present studies were undertaken to examine its interaction and that of its desialylated variant asialo-hCG with recombinant human TSH (hTSH) receptor (hTSHr). To this end, we transfected a human thyroid carcinoma cell line (HTC) lacking endogenous TSHr with the full-length cDNA of the hTSHr. Unlike the wild type, the transfected cells, termed HTC-TSHr c...
متن کامل[Urinary hCG beta-core fragment as a tumor marker for bladder cancer].
Human chorionic gonadotropin (hCG) is a highly specific tumor marker or trophoblastic neoplasms. Also in patients with non-trophoblastic tumors, hCG beta-related material has been frequently demonstrated in their urine. This material was termed beta-core fragment (beta-CF) since it is recognized by hCG beta-core directed antisera but not by hCG beta-carboxyterminal peptide (CTP) directed antise...
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Fragment” Production Evaluated in Patients wfth Gynecological Neoplasms, Patrick Neven,”2 Ray K I/es,3 Paul G. Carter,’ John H. Shepherd,’ and Tim Chard3 [1 Gynecol. Once!. Unit, St. Bartholomew’s Hosp. and the Royal Marsden Hosp., London; 2A mene Kliniek St. Jan, Broekstraat 1000, Brussels, Belgium (address for correspondence), fax 32-2-219-86-96; 3Wilhianison Lab. for Molec. Oncol., St. Barth...
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Deep B and R images of three Hickson Compact Groups, HCG 79, HCG 88 and HCG 95, were analyzed using a new wavelet technic to measure possible intra-group diffuse light present in these systems. The method used, OV WAV, is a wavelet technic particularly suitable to detect low-surface brightness extended structures, down to a S/N = 0.1 per pixel, which corresponds to a 5-σ-detection level in wave...
متن کاملScreening method to evaluate point-of-care human chorionic gonadotropin (hCG) devices for susceptibility to the hook effect by hCG β core fragment: evaluation of 11 devices.
BACKGROUND The predominant hCG variant in urine, hCG β core fragment (hCGβcf), has been demonstrated to cause false-negative results in qualitative point-of-care (POC) hCG devices. This is a major concern for healthcare professionals using POC pregnancy tests. We developed a screening method to evaluate qualitative POC hCG devices for their susceptibility to inhibition by hCGβcf. Using this met...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2000
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe.0.1640299